Objective: to consider sustainable development of a region with mining as predominant economic activity through the prism of the relationship between technological and environmental aspects; to determine the impact of technological development of the coal-mining region on its sustainable development.Methods: the methods of statistical observation,
From Structural Studies to HCV Vaccine Design
Hepatitis C virus (HCV) is a serious and growing public health problem despite recent developments echofix spring reverb of antiviral therapeutics.To achieve global elimination of HCV, an effective cross-genotype vaccine is needed.The failure of previous vaccination trials to elicit an effective cross-reactive immune response demands better vaccine
Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells
Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features.Methods In this study, single-cell RNA sequencing (scRNA-seq) was used to profile the distinct tumor microenviron
Ecological carrying capacity and carbon sequestration potential of bivalve shellfish in marine ranching: A case study in Bohai Bay, China
IntroductionShellfish play an important role in ecological restoration and as carbon (C) sinks, but studies on their ecological carrying capacity (ECC) and C sequestration potential are sparse.MethodsIn this study, we selected a 57-hectare bostik universal primer pro artificial oyster reef in a typical marine ranching in Bohai Bay, China, to evalua